TU Delft
Year
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NEDERLANDSENGLISH
Organization
2015/2016 Applied Sciences Master Nanobiology
NB4040
Biology of Cancer
ECTS: 4
Responsible Instructor
Name E-mail
Prof.dr. L.H.J. Looijenga    L.H.J.Looijenga@tudelft.nl
Instructor
Name E-mail
Prof.dr. H.R. Delwel    H.R.Delwel@tudelft.nl
Prof.dr. I.P. Touw    I.P.Touw@tudelft.nl
Contact Hours / Week x/x/x/x
0/8/0/0/
Education Period
2
Start Education
2
Exam Period
2
3
Course Language
English
Course Contents
In this course the student will learn how cancer is initiated and promoted through a multi-step process. Oncogenes, tumor suppressor genes and viruses, the drivers of cancer, will be discussed. The course will address how key processes for the progression of cancer, signal transduction, cell cycle control, telomere homeostasis, and cell metabolism, are deregulated. The importance of cell-cell interactions and cell migration for tumor metastasis, as will as angiogenesis, resistance mechanisms to apoptosis and immune surveillance escape will be discussed. Classification among tumors based on classical histology will be contrasted to new molecular approaches to detect subgroups within tumors. The working mechanisms of classical anti-cancer treatments will be presented and compared and contrasted to precision medicine approaches made possible by genome-wide molecular characterizations.
Study Goals
At the completion of this course, the students will be able:
Describe the hallmarks of cancer
Demonstrate understanding of how oncogenes, tumor suppressor genes and viruses promote cancer
Demonstrate understanding of signal transduction in the context of cancer
Describe the rational behind precision medicine approaches in cancer treatment.
Education Method
Lectures and workgroups
Literature and Study Materials
Required:
Lecture notes & articles provided during the course
The Biology of Cancer, Robert A. Weinberg, Garland Science
Books
Required:
Lecture notes & articles provided during the course
The Biology of Cancer, Robert A. Weinberg, Garland Science
Assessment
Written exam
Location
Rotterdam